The incidence of invasive Group A Streptococcus (GAS) reached the highest ever recorded figures in Sweden last year. In the event of an invasive infection, the bacterium spreads like wildfire in the body. Sepsis is difficult to detect at an early stage and the course of the disease is rapid,

The main objective of this project is to explore the potential of using the outer ear; including the concave side of the pinna, the external and internal auditory canal, and the tympanic membrane, as a platform to gain further understanding of how alternative pathways through the skin contribute to transdermal

Every day I see patients who die prematurely or lose quality of life due to low blood pressure. A PVC that can be placed quickly and safely yet deliver large volumes of fluid rapidly would save lives and preserve quality of life for patients surviving critical illness. Difficulty establishing free

Mutations in the estrogen receptor are responsible of resistance to standard treatments, and so far no effective alternative drug regimens have been implemented in the clinic. We believe that our proteogenomic workflow can be applied to analyze clinical samples with expressed estrogen receptor mutations to derive alternative drug targets and

Our project aims to diagnose and characterise sepsis and ultimately tailor the treatment of sepsis and ARDS using protein profiles. Today, new proteomics methods (such as mass spectrometry) can analyse thousands of proteins at a time from a drop of blood. Our hope is that with protein profiling and artificial

The aim of the project is to investigate the connection between diet/berries, microbiota and the effect on cognition and the pathological changes linked to Alzheimer’s disease. Above all, we hope to be able to find links to APOE4, which half of all Alzheimer’s patients have, and which is a cholesterol-carrying

Most surgical interventions (biopsy collections, microinjections, implant insertions, etc.) in the brain are performed with little regard to the mechanical forces that are generated in the various brain structures. Our findings suggest that unique surgical force-mitigation strategies represent a significant advance and a unique commercial opportunity. This work is of

In Sweden alone, there are > 30,000 strokes/year, causing major impact on individuals and society (16 B SEK/year). During the 80 000 annual ultrasound examinations, most individuals with dangerous plaques are missed, as there is currently no method to assess plaque composition. Our method is needed for 1) clinical investigations,

Cancer treatment has never been better than it is today. This also implies that today more people than ever are living with a cured or surgically removed cancer. Unfortunately, this often means a lifelong risk of relapse. Individualized cancer vaccines could reduce that risk for many millions of people globally.

Classical tissue engineering strategies are patient-specific, thus clearly associated with inherent limits: a time-consuming graft production and a complex/costly production. Most importantly those cell-based strategy only allows for autologous use of the generated grafts. Here, we will validate the large-scale production and pre-clinical performance of a unique bone graft substitute.