Mutations in the estrogen receptor are responsible of resistance to standard treatments, and so far no effective alternative drug regimens have been implemented in the clinic. We believe that our proteogenomic workflow can be applied to analyze clinical samples with expressed estrogen receptor mutations to derive alternative drug targets and

Our project aims to diagnose and characterise sepsis and ultimately tailor the treatment of sepsis and ARDS using protein profiles. Today, new proteomics methods (such as mass spectrometry) can analyse thousands of proteins at a time from a drop of blood. Our hope is that with protein profiling and artificial

Classical tissue engineering strategies are patient-specific, thus clearly associated with inherent limits: a time-consuming graft production and a complex/costly production. Most importantly those cell-based strategy only allows for autologous use of the generated grafts. Here, we will validate the large-scale production and pre-clinical performance of a unique bone graft substitute.

The aim of the project is to investigate the connection between diet/berries, microbiota and the effect on cognition and the pathological changes linked to Alzheimer’s disease. Above all, we hope to be able to find links to APOE4, which half of all Alzheimer’s patients have, and which is a cholesterol-carrying

Most surgical interventions (biopsy collections, microinjections, implant insertions, etc.) in the brain are performed with little regard to the mechanical forces that are generated in the various brain structures. Our findings suggest that unique surgical force-mitigation strategies represent a significant advance and a unique commercial opportunity. This work is of

In Sweden alone, there are > 30,000 strokes/year, causing major impact on individuals and society (16 B SEK/year). During the 80 000 annual ultrasound examinations, most individuals with dangerous plaques are missed, as there is currently no method to assess plaque composition. Our method is needed for 1) clinical investigations,

Cancer treatment has never been better than it is today. This also implies that today more people than ever are living with a cured or surgically removed cancer. Unfortunately, this often means a lifelong risk of relapse. Individualized cancer vaccines could reduce that risk for many millions of people globally.

The purpose of the project is to find out if the technology and methods function in human kidneys as well as validate the product prototype to pave the way for efficient and successful commercialization, i.e., the first part of the clinical study. Through this, the number of donor kidneys available

We are developing objective and quantitative measurement tools that measure cerebellar function in combination with a modernized motor assessment test. We believe this can potentially revolutionize the way we assess and study ADHD and ASD – two diagnoses that cover several hundred thousand children in Sweden alone. In fact, our

The ”nurse car” is a new service which means that an experienced nurse comes to your home and make a medical assessment, provide advice and assess the level of care required.