Modulation of the gut-brain axis by probiotic supplementation in an obesity mouse model

Our overall purpose is to demonstrate that novel bacterial strains can prevent obesity and associated comorbidities. This pre-clinical proof-of-concept project aims at testing the efficacy of 4 anaerobic butyrate-producing bacterial strains in reducing gut inflammation, promoting metabolic health, and improving brain function. Promising strain will be further evaluated in clinical trials, and then developed into functional food products or supplements for a next-generation probiotics.