Development of new sequential technology to map gene changes in situ in the human brain

Changes in the balance between different proteins and their coded original mRNA are vital to the normal function of the brain. However, in neurological diseases such as Alzheimer’s, epilepsy and Parkinson’s, the changes over time lead to a negative spiral that results in neurodegeneration and cell death. Studying these changes by mapping the expression pattern of mRNA in the tissue has created an invaluable window into these processes. The project wants to build the first prototype of sequential technology and use it to map for the first time the change that occurs in the human brain during epilepsy.