Analysis of mycobacterial strains with whole genome sequencing

Tuberculosis (TB) is a disease that obligates the tracing of the contagion which is transmittable among both children and adults. Quick detection of the disease, including forms which are resistant to one or more major antibiotics, is essential for the proper management and efficient tracing of the contagion. The primary objective is to compare the “whole genome sequencing” (WGS) with results from traditional genotypic analysis in order to study whether WGS provides new information about the evolution of M. tuberculosis during an outbreak of the disease, and to show whether WGS can be used in future gene-based molecular epidemiological studies.